yes you can make them you just need to make manually landmarked and xseg'd head facesets and currently I use a animal dst during training to make it work on animals all my dfms not just Humans But if someone wanted to make a Simpsons and family guy and furturama and south park and others DST I would 100% use it.
And also make sure to include tongue and whole head and stuff and also include Obstruction images in the DST as well for best support